منابع مشابه
Serine metabolism in rat liver slices.
While much is known of the various pathways of serine metabolism, there is little quantitative information concerning the relative importance of each. The present study has, therefore, been undertaken to examine the over-all pattern of serine metabolism in surviving rat liver slices. It seems likely that serine is in the major pathway for both the synthesis of glycine and “l-carbon” compounds f...
متن کاملImatinib metabolism and disposition in isolated rat perfused liver
Imatinib is an orally administered tyrosine kinase inhibitor which inhibits the Bcr-Abl protein-tyrosine kinase with high selectivity. Imatinib is rapidly absorbed from the gut, after oral intake and has an almost absolute bioavailability of 98%. The metabolism of imatinib is mediated by the cytochrome P450 (CYP) isoenzymes in the liver and gut wall. CGP74588 is a major active metabolite of ima...
متن کاملPropionic acid metabolism in mouse liver slices.
Odd carbon fatty acids are considered to be oxidized in tissue by successive fl oxidation in much the same way that even carbon members of the series are (14). The terminal S-carbon unit has been investigated to some extent. Atchley (5) demonstrated propionic acid as an end-product in the oxidation of valeric acid by a rabbit enzyme system. Studies on malonate inhibition with odd carbon fatty a...
متن کاملSerine metabolism in rat embryos undergoing organogenesis.
Rat embryos (9.5 days gestation) were cultured for 48 h in heat-inactivated homologous serum containing [3-14C] serine. Analysis of the distribution of the radioactive label in the conceptus demonstrated that almost one half of the incorporated serine was cleaved to provide one-carbon units for the synthesis of purine and pyrimidine nucleotides. Analysis of the free amino acids in the serum, th...
متن کاملStudies on carbohydrate metabolism in rat liver slices. VI. Hormonal factors influencing glucose-6-phosphatase.
In any consideration of carbohydrate metabolism of the liver, glucose-6phosphate plays an important r81e. Glucose must first be phosphorylated to glucose-6-phosphate in order to enter the glycolytic pathway to form glycogen and fat for storage, or to be burned for energy. On the other hand, liver phosphatase must split glucose-6-phosphate into glucose and inorganic phosphate before stored carbo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1957
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)70855-7